Duygu MURAT ÖZTÜRK
1Amasya University Faculty of Health Sciences, Amasya, TURKEY
Title: Effects of Syntetic Oxytocin on the Birth Process and Some of the Labor Hormones
Biography
Biography: Duygu MURAT ÖZTÜRK
Abstract
In this study, effects of synthetic oxytocin application on the labor process and the birth hormones of rats were investigated.
Pregnant Sprague Dawley rats (n=18) were divided into three groups including control group, synthetic oxytocin injected group and physiological saline solution injected group. Synthetic oxytocin was injected on 20th and 21th days of gestation. All rats were subjected to open field test for 5 minutes at the last trimester. Blood samples were taken from the tail vein at the beginning of birth to measure ten different parameters (including Corticotropin-releasing hormone, oxytocin, endorphin, epinephrine, norepinephrine, prolactin, estrogen, progesterone, vasopressin and Brain Derived Neurotrophic Factor) that are involved in the labor process.
Kruskal Wallis and Mann Whitney U tests were used to compare data by using MedCalc Statistical Software program (version 12.7.7). Correlation of two continuous variables that did not display normal distribution was done by Spearman's rho correlation analysis.
In one of the animals injected synthetic oxytocin, a cardiac defect was detected. However, this result was statistically insignificant, since it was the only case in the experimental group. Levels of progesterone and BDNF were significantly (p<0.05) different between synthetic oxytocin and physiological saline solution injected groups. While the mean oxytocin level was the lowest in the synthetic oxytocin injected group; the mean endorphin level was the highest in the control group. These hormonal changes were not affected the physiology of birth. However, routine interventions should be avoided as much as possible.